Toxic epidermal necrosis
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Kaleungitan kulit karakteristik Toxic epidermal necrosis
References
Stevens-Johnson Syndrome (SJS) jeung Toxic Epidermal Necrolysis (TEN) mangrupakeun kaayaan langka dimana kulit ngalaman nekrosis éksténsif jeung shedding. Dina hal pengobatan, cyclosporine pohara efektif pikeun SJS, sedengkeun kombinasi immunoglobulin intravena (IVIg) sareng kortikosteroid dianggo pangsaéna pikeun kasus SJS sareng TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) mangrupakeun réaksi kulit serius disababkeun ku pangobatan tangtu jeung aktivitas sistim imun, hasilna detachment skala badag tina lapisan kulit luar (épidermis) , mangaruhan leuwih ti 30% beungeut awak. TEN ngagaduhan tingkat kematian langkung ti 20%, sering kusabab inféksi sareng kasusah engapan. Ngeureunkeun pangobatan anu nyababkeun réaksi, nyayogikeun perawatan anu ngadukung, sareng nganggo pangobatan tambahan tiasa ningkatkeun hasilna. Panaliti anyar nunjukkeun yén ubar sapertos cyclosporine, inhibitor alfa faktor nekrosis tumor, sareng kombinasi globulin imun intravena sareng kortikosteroid tiasa ngabantosan, dumasar kana uji coba anu dikontrol sacara acak sareng analisa sababaraha panilitian.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
Anu ngabalukarkeun paling umum nyaéta pangobatan tangtu sapertos lamotrigine, carbamazepine, allopurinol, antibiotik sulfonamide, sareng nevirapine. Faktor résiko kalebet HIV sareng lupus erythematosus sistemik. Perawatan biasana lumangsung di rumah sakit sapertos di unit kaduruk atanapi unit perawatan intensif.
○ Perlakuan
Ieu mangrupikeun panyakit anu serius, janten upami biwir atanapi sungut anjeun kapangaruhan atanapi kulit anjeun janten lepuh, tingali dokter anjeun pas mungkin.
Obat anu curiga kedah dileungitkeun. (misalna antibiotik, ubar anti radang non-stéroid)