Toxic epidermal necrosis
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Kaleungitan kulit anu khas dina Toxic epidermal necrosis.
relevance score : -100.0%
ReferencesStevens-Johnson Syndrome (SJS) jeung Toxic Epidermal Necrolysis (TEN) mangrupakeun kaayaan langka dimana kulit ngalaman nekrosis éksténsif jeung shedding. Dina hal pangobatan, cyclosporine pohara efektif pikeun SJS, sedengkeun kombinasi immunoglobulin intravena (IVIg) jeung kortikosteroid dipaké salaku pangobatan pangalusna pikeun kasus SJS jeung TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) mangrupakeun réaksi kulit anu serius disababkeun ku pangobatan tangtu jeung aktivitas sistem imun, hasilna nyaéta leupasna (detachment) skala badag tina lapisan kulit luar (epidermis), anu mangaruhan leuwih ti 30 % beungeut awak. TEN ngagaduhan tingkat kematian langkung ti 20 %, sering kusabab inféksi sareng kasusah engapan. Ngeureunkeun pangobatan anu nyababkeun réaksi, nyayogikeun perawatan suportif, sarta nerapkeun pangobatan tambahan tiasa ningkatkeun hasilna. Panaliti anyar nunjukkeun yén ubar sapertos cyclosporine, tumor necrosis factor‑alpha inhibitor (inhibitor alfa faktor nekrosis tumor), sareng kombinasi intravenous immunoglobulin (globulin imun intravena) jeung corticosteroid (kortikosteroid) tiasa ngabantosan, dumasar kana uji coba acak terkontrol jeung analisis sababaraha panalungtikan.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
Anu ngabalukarkeun paling umum nyaéta pangobatan tangtu sapertos lamotrigine, carbamazepine, allopurinol, sulfonamide antibiotics, jeung nevirapine. Faktor résiko kalebet HIV sareng lupus erythematosus sistemik. Perawatan biasana dilakukeun di rumah sakit, contona di unit kaduruk atawa unit perawatan intensif.
○ Perlakuan
Ieu panyakit serius, jadi upami bibir atawa sungut anjeun kapangaruhan atawa kulit anjeun jadi lepuh, geura tingali dokter sabisa‑bisa.
Obat anu curiga kedah dileungitkeun (misalna antibiotik, non‑steroidal anti‑inflammatory drugs (NSAIDs)).